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Inflammation and the Host Response
to Injury is a large-scale collaborative research program
supported by the National Institute of General Medical Sciences,
a division of the National Institutes of Health. Our NIH investigators
agreed that the most important biological problem to tackle
in the area of injury research centered on the innate inflammatory
response, and specifically, to improve our systems level understanding
of the key regulatory elements, and their relative roles and
importance that drive the host's response to serious injury
and its accompanying severe systemic inflammation
The problem could only be addressed by first acquiring large
amounts of new data ("discovery-driven approach"). It was evident
to our participating investigators that our limited success
in developing appropriate therapeutic interventions for the
treatment of the severe trauma or burn injured patient has been
the result of an incomplete understanding of the integrated
host response to injury. The excitement of the group focused
on our potential to pay attention to experimental detail and
data gathering capacity along with the potential to derive greater
accuracy and informational content in ever smaller and more
enriched samples, and to ultimately introduce genome-wide microarray
technologies and high throughput proteomics to clinical medicine.
Such an improved understanding would lead to genomic and proteomic
markers that predict ultimate outcomes both good and bad, and
would suggest new targets for further basic and clinical research,
as well as fruitful targets for pharmacological and immunomodulatory
interventions.
We continue our work towards reaching our Program deliverables
and contributions, which should include: (1) a well-annotated
clinical database of rich genomic and proteomic information;
(2) new technology for application in clinical studies (microfluidic
cell separations, novel custom gene chip); (3) novel bioinformational,
statistical and pathway analysis tools for the exploration of
the genomic and proteomic data; and (4) gene sets with high
predictability of multiple organ failure and other clinical
trajectories.
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Glue Grant Publications
A full listing of articles published based on Glue Grant research
from its inception in 2001 until the present is now available. Click
on the following link for a list of these publications. <Publications
list - MS Word document>
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| The Trauma-Related Database Concept
 One
of the principal products or deliverables of our planned 10-year award,
the Trauma Related Database (TRDB) is a large, relational database
warehouse containing clinical, proteomic, cell biology, and gene expression
data from our trauma and burns patients and healthy control subject
studies. The TRDB provides a browser interface for downloading complete
datasets, and more importantly, user-selected data subsets.
Data can be downloaded as tables (i.e., relational format) and as
binary or text files for use in various data analysis applications.
Refinements to enhance the query and report-writing capabilities of
TRDB are also a component of our funded research program.
The program data warehoused in TRDB undergoes a vigorous process of
scientific annotation, validation, and curation to insure that the
data are of maximum usefulness to the scientific community. Access
to the curated data in TRDB is available now to our Consortium
Members to meet the NIH requirements of timely and responsible release
of data. More...
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